
Love is universal, or at least it seems to be. 
Every society has a romantic tradition, and the desire to form a long
 and (hopefully) lasting love with another human being is apparently an 
intrinsic part of being human.  But while monogamy seems to be the ideal
 for most people, attaining that ideal is easier said than done. Like it
 or not, humans aren't likely to stay with one romantic partner for 
their entire lives. No matter how a society chooses to define marriage, nearly half of all such partnerships end in divorce. 
This is hardly unique to modern society: According to David Buss, (link is external)
 hunter-gatherer societies seem particularly prone to divorce. For 
example, members of the Ache society of Paraguay can report as many as 11 marriages by the time they reach adulthood (link is external). 
For whatever reason, most romantic relationships are going to come to an end, whether harmoniously or not.  
Though we recognize that love is often fragile, it can be difficult to understand exactly why a romantic relationship comes to an end. For most people, this can be a traumatic experience, especially for the one who is caught unaware that a relationship is over. The shock and anger that can result from a bad breakup can take years to work through; learning to move on can be extremely difficult. 
While there has been extensive research into the psychology of 
romantic love, is it possible to learn what can cause people to fall out
 of love with a significant other? For that matter, how is it possible 
to move on after such a relationship comes to an end? A new article 
published in Review of General Psychology (link is external)
 suggests that humans may actually have a mental mechanism in place for 
severing the emotional bond between romantic partners. Authors Brian 
Boutwell of Saint Louis University, J.C. Barnes of the University of 
Cincinnati, and Kevin Beaver of Florida State University suggest in 
their article that their concept of a "mate rejection module" is hardly 
new.
Evolutionary psychologists have long argued that the ability to end a
 relationship and prepare for a new one can have definite advantages in 
terms of improving the ability to reproduce successfully. While some 
species can mate for life, humans typically don't. Admittedly, there are
 enormous differences across cultures—and at different periods in 
history—which makes it difficult to pin down how the mate rejection 
module actually works. Not only have some cultures allowed multiple 
marriages, but ending a marriage has been extremely difficult in many 
times and places. Even with casual relationships that don't involve any 
formal declarations, moving on from one partner to the next one can 
still be tricky. 
In their review, Boutwell and his co-authors suggest that there are can be separate mechanisms at work:
- First is what they called primary mate ejection, or the active decision to reject a mate.
 - Secondary mate ejection involves coming to terms with being rejected and reaching the point at which a new romantic pairing becomes possible.
 
Not surprisingly, there appear to be significant differences 
between males and females in terms of where and when their mate ejection
 modules are activated. When dealing with infidelity,
 for example, men and women may react very differently, depending in 
part on how serious the infidelity is considered to be. Since, in 
evolutionary terms, men are more sensitive to the possibility of raising
 someone else's child, they may be less prone to forgive sexual infidelity than women. On the other hand, women seem less prone to forgiving emotional
 infidelity—such as when a partner falls in love with another woman, 
rendering him no longer a "safe bet" in terms of supporting her children
 (or her). Studies examining how willing men and women are to forgive 
infidelity appear to support this gender difference. 
The kind of resources that a woman has, and the opportunities within 
the culture in which she lives, can also affect how willing she is to 
eject a mate. If she is able to support herself, the decision to leave 
is often easier than if she might be left destitute following a split. 
But is it possible to use neuroscience to understand how mate ejection works for men and women? 
In their article, Boutwell and his colleagues examined some of the 
neurological underpinnings of romantic love, including fMRI studies 
showing that many of the brain pathways linked to being in love show 
strong similarities with pathways linked to addiction. (Didn't you always suspect that?)
These pathways include the orbitofrontal and prefrontal cortex, right
 ventral tegmental area, and the ventral striatum, all of which involve 
reward or pleasure areas of the brain. The love-addiction link also 
helps explain the acute distress people feel when rejected by a romantic
 partner, as well as why stalkers have so much trouble letting go of 
their romantic feelings. 
While the feeling associated with mate ejection can resemble drug 
withdrawal in many ways, both primary and secondary mate ejection take 
place after a gradual process of overcoming these old feelings and 
preparing the brain for bonding to a new partner. Once mate ejection 
occurs (whether primary or secondary), parts of the prefrontal cortex 
begin the process of "learning" to prepare for a new romantic interest. 
(An intriguing example of how brain biochemistry can affect mate ejection involves research looking at selective serotonin reuptake inhibitor (SSRI) anti-depressants.  By suppressing serotonin levels, the brain's dopamine and norepinephrine levels are affected as well. Not only does this lower testosterone
 levels, but it may also suppress romantic feelings. For men, this might
 trigger a preference for sexual variety and, as a result, increase the 
risk of infidelity. For now, Boutwell et al. simply raise this as a 
possible explanation for why men may become more sexually promiscuous as
 a side effect of using these medications, but it can also be help 
understand how biochemical changes could lead to relationship problems.)
There remain numerous unanswered questions about mate ejection:
- Is it the same for both homosexual and heterosexual relationships? While early studies suggest that it is, this is still largely open to debate.
 - Then there is the question of how mate ejection can be measured. Can the same brain pathways that seem to be involved in romantic love be linked to the decision to end a relationship?
 - And what about cases of obsessive love, such as erotomania? Could understanding more about mate ejection help with treatment of stalkers?
 
All of these questions are potential areas for future research.
"Til death do us part" pairings do exist, of course, but for whatever
 reason, most romantic relationships will eventually come to an end. 
Whether the breakup that ends a love affair is mutual or one-sided, we 
all have the capacity to move on to someone else, even if coping with 
heartache and disappointment can be overwhelming at times.  
In many ways, ending a love affair is a lot like overcoming a drug 
addiction—and brain research seems to bear this out. However we first 
evolved the capacity for mate ejection, it seems to have become an 
important part of the human condition. Learning more about mate ejection
 may also provide the key to understanding how to keep love alive for as long as humanly possible.
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